AX-03 · MITO-SERIES · MITOCHONDRIAL BIOGENESIS & DEFENSE
The first mitochondrial biogenesis serum that doesn't just shield existing skin cells, it sparks brand-new cellular power plants.
Standard antioxidants only defend the aging mitochondria you have left. Mito-Reset goes one step further: pairing L-Ergothioneine with Pyrroloquinoline Quinone (PQQ Disodium Salt), a redox coenzyme shown to support up to 5,000× more redox-cycling efficiency than Vitamin C while activating the PGC-1α mitochondrial biogenesis pathway. Supercharged with a Triple-Peptide Complex, Niacinamide (#4), and Panthenol (#5) in a weightless, phenoxyethanol-free daily serum.
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Small-batch production
Due to the nature and rarity of the ingredients used, this serum is produced in very limited batches.
The Generator. The Bodyguard. The Triple-Peptide Complex.
Water, Glycerin, Butylene Glycol, Niacinamide, Panthenol, Carbomer, Arginine, Xanthan Gum, Glyceryl Polymethacrylate, Ergothioneine, Pyrroloquinoline Quinone Disodium Salt, Sodium Hyaluronate, Abronia Villosa Leaf Extract, Acetyl Hexapeptide-8, Acetyl Octapeptide-3, Palmitoyl Tripeptide-1, Silk Amino Acids, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, 1,2-Hexanediol, Caprylhydroxamic Acid, Ethylhexylglycerin, Parfum, 1,2-Pentanediol, Portulaca Oleracea Extract.
Formula C261022A · Contains Parfum.
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Pure Vitamin C (L-Ascorbic Acid) must be formulated at an irritatingly low pH (<3.5), oxidizes rapidly into brown pro-oxidant water when exposed to air, and is consumed after neutralizing a single free radical. Pyrroloquinoline Quinone (PQQ Disodium Salt) and L-Ergothioneine operate at a skin-friendly neutral pH, never sting, and sustain up to 5,000× more catalytic redox cycles than Vitamin C while actively stimulating the creation of new mitochondria (mitochondrial biogenesis).
Mito-Reset builds upon our foundational L-Ergothioneine + Dual Peptide architecture by adding Pyrroloquinoline Quinone Disodium Salt (PQQ) for PGC-1α mitochondrial biogenesis, upgrading from a dual-peptide to a Triple-Peptide System (adding Palmitoyl Tripeptide-1 alongside Acetyl Hexapeptide-8 and Acetyl Octapeptide-3), elevating Panthenol to #5 on the INCI list, adding soothing Purslane Extract, and utilizing a 100% phenoxyethanol-free preservation system (Caprylhydroxamic Acid).
Pure PQQ Disodium Salt naturally imparts a warm, golden-amber to subtle rosy-champagne hue depending on concentration, with zero synthetic dyes.
Yes. For optimal results without overloading your skin, we recommend using Mito-Reset every morning under SPF (where L-Ergothioneine, PQQ, Niacinamide, and expression peptides defend against daylight UV stress and squinting) and Mito-Matrix (GHK-Cu + NAD+) or your retinoid at night. However, because Mito-Reset is pH-neutral and copper-free, it can also be used both morning and night if you do not use a separate PM treatment.
High-dose Niacinamide (#4), Panthenol (#5), and Sodium Hyaluronate deliver immediate surface hydration and barrier calm from day one. Dynamic expression lines softened by Argireline + SNAP-8 typically appear smoother within 2 to 4 weeks, while deeper radiance, pore refinement, and collagen firmness from PQQ, L-Ergothioneine, and Palmitoyl Tripeptide-1 compound over 6 to 12 weeks.
Combines PQQ Disodium Salt and L-Ergothioneine to support mitochondrial biogenesis and defend against daily photo-oxidative dullness.
Pairs Acetyl Hexapeptide-8 (Argireline) with its advanced octapeptide sister, Acetyl Octapeptide-3 (SNAP-8), to visibly relax repetitive forehead, glabella, and crow's feet creasing.
Includes Palmitoyl Tripeptide-1 (Matrixyl) alongside Silk Amino Acids and L-Arginine (#7) to signal and feed structural dermal firmness.
Formulated with Niacinamide at #4 and Panthenol at #5 on the label to visibly refine pores, calm redness, and strengthen your ceramide lipid shield.
Silicone-free, oil-free, and phenoxyethanol-free. Absorbs in seconds with zero pilling under sunscreen or makeup.
Originally discovered as a bacterial redox coenzyme and dubbed a "longevity vitamin" by biochemists, PQQ Disodium Salt is one of the only known molecules proven to stimulate mitochondrial biogenesis—the creation of brand-new mitochondria inside aging cells. By phosphorylating CREB and activating the SIRT1 / PGC-1α master regulator pathway, PQQ increases cellular NAD+ formation and sustains 100 to 5,000 times more redox cycles than Vitamin C without degrading.
Human cells possess a dedicated genetic transporter (OCTN1) evolved specifically to pull L-Ergothioneine directly into the mitochondria. In published tri-axis longevity models (Sun et al., 2026, Redox Biology), while PQQ generates new mitochondria, L-Ergothioneine neutralizes mitochondrial superoxide and singlet oxygen—clearing out the toxic byproducts of elevated cellular energy production before they can trigger collagen-degrading MMP enzymes or pigmentation.
Why settle for a single peptide pathway? Mito-Reset combines two complementary neuro-modulating expression peptides—Acetyl Hexapeptide-8 (Argireline) and Acetyl Octapeptide-3 (SNAP-8)—to soften tension-induced squint lines, paired with Palmitoyl Tripeptide-1, a fatty-acid-linked collagen signal peptide that supports dermal density and bounce.
Anchored at #4 and #5 on our INCI list, clinical-grade Niacinamide (Vitamin B3) and Panthenol (Pro-Vitamin B5) team up with Portulaca Oleracea (Purslane)—a botanical rich in natural glutathione—and Abronia Villosa (Desert Sand Verbena) to calm UV erythema, inhibit melanosome transfer, and lock water deep inside the epidermis.
REDOX CYCLING
ASCORBIC ACID: 1 REDOX CYCLE → PQQ: UP TO 5,000 REDOX CYCLES
THE ENERGY BOTTLENECK
AGING FIBROBLAST: MITOCHONDRIAL DEPLETION & ROS LEAK
THE GENERATOR + THE BODYGUARD
PQQ (NEW MITOCHONDRIA) + L-ERGO (ROS CLEARANCE) + 3 PEPTIDES
THE MOMENT YOU NOTICE
You wear SPF 50+ every morning and layer Vitamin C underneath, yet by mid-afternoon your skin still looks flat, dull, and etched with expression lines that used to bounce right back.
Fresh cellular energy. Smoother lines. More glow.
INGREDIENT RESEARCH
Engineered around cellular bio-energetics and published longevity research.
In landmark biochemical research published in the Journal of Biological Chemistry, Pyrroloquinoline Quinone (PQQ) was proven to stimulate mitochondrial biogenesis—increasing mitochondrial DNA content, cytochrome c oxidase activity, and cellular oxygen respiration—through CREB phosphorylation and increased PGC-1α expression (Chowanadisai et al., 2010, J. Biol. Chem. 285:142–152).
Published ingredient research · not a clinical trial on finished Mito-Reset serum.
Comparative chemical assays measuring redox cycling demonstrate that PQQ is 100 to 5,000 times more efficient at sustaining continuous electron transfer than common antioxidants like ascorbic acid (Vitamin C), undergoing thousands of reductive and oxidative cycles without polymerizing or self-degrading (Paz et al. / US Patent 10,799,441 B2;MDPI Antioxidants 2024).
In vitro chemical redox assay on PQQ · individual cosmetic results vary.
In the 2026 Tri-Axis Mitochondrial Anti-Aging Model (Sun et al., 2026, Redox Biology), researchers established that while PQQ stimulates AMPK and PGC-1α to generate new mitochondria and elevate NAD+ via the SIRT1 pathway, L-Ergothioneine (EGT) is required to neutralize the resulting mitochondrial ROS and prevent inflammatory cellular senescence.
Published longevity mechanism model · establishes formulation rationale.
Published studies in the Journal of Nutritional Science and Vitaminology and BioMed Research International demonstrate that PQQ improves skin moisture retention and epidermal barrier function while counteracting UVA-induced cellular senescence and matrix metalloproteinase (MMP) collagen breakdown (Nakano et al., 2015, JNSV 61:241; Li et al., 2022).
Published active ingredient literature · cosmetic appearance support only.
INSIDE THE COMPLETE FORMULA
PQQ Disodium Salt and L-Ergothioneine lead our dual-axis mitochondrial core, backed by three targeted peptides, high-dose B-vitamins (#4 & #5), and extremophile botanicals.
SYSTEM 01· MITOCHONDRIAL BIOGENESIS & REDOX SHIELD
A synergistic longevity duo where PQQ activates PGC-1α mitochondrial renewal and catalytic redox cycling, while L-Ergothioneine quenches intra-mitochondrial ROS and oxidative stress.
SYSTEM 02 · TRIPLE-PEPTIDE EXPRESSION & COLLAGEN MATRIX
Targets both dynamic surface expression creases (via dual SNARE-complex hexapeptide and octapeptide modulation) and structural dermal firmness (via fibroblast collagen signaling).
SYSTEM 03 · BARRIER FORTIFICATION & TONE PERFECTION
Placed at the top of the formula to visibly brighten uneven pigmentation, replenish natural ceramides, supply collagen amino acid building blocks, and cushion reactive skin.
SYSTEM 04 · EXTREMOPHILE BOTANICAL & MULTI-DIOL DELIVERY
Suspends Hyaluronic Acid and antioxidant-rich botanical extracts inside a phenoxyethanol-free 1,2-Hexanediol, 1,2-Pentanediol, and Butylene Glycol carrier matrix for rapid, zero-tack absorption.
FULL INCI · C261022A
Water, Glycerin, Butylene Glycol, Niacinamide, Panthenol, Carbomer, Arginine, Xanthan Gum, Glyceryl Polymethacrylate, Ergothioneine, Pyrroloquinoline Quinone Disodium Salt, Sodium Hyaluronate, Abronia Villosa Leaf Extract, Acetyl Hexapeptide-8, Acetyl Octapeptide-3, Palmitoyl Tripeptide-1, Silk Amino Acids, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, 1,2-Hexanediol, Caprylhydroxamic Acid, Ethylhexylglycerin, Parfum, 1,2-Pentanediol, Portulaca Oleracea Extract.
Every active, peptide, humectant, and carrier disclosed transparently.
PQQ Disodium Salt outlasts conventional Vitamin C without stinging or oxidizing on the skin.
Combines Argireline, SNAP-8, and Matrixyl.
Preserved gently with coconut-derived Caprylhydroxamic Acid and dual diols.
| INCI position | Ingredient | Role in Mito-Reset |
|---|---|---|
| #1 | Water | Ultra-purified aqueous base. |
| #2 | Glycerin | Biomimetic humectant that draws moisture into intercellular aquaporin channels. |
| #3 | Butylene Glycol | Primary penetration enhancer that increases peptide and coenzyme bioavailability. |
| #4 | Niacinamide | High-Dose Vitamin B3. Boosts ceramide synthesis, refines pores, evens skin tone, and feeds cellular NAD+ salvage. |
| #5 | Panthenol | High-Dose Pro-Vitamin B5. Deeply hydrates, calms visible redness, and cushions the skin barrier. |
| #6 | Carbomer | Creates a weightless, fast-breaking water-gel texture that never pills under SPF. |
| #7 | Arginine | L-Arginine. Essential collagen amino acid building block and nitric oxide micro-circulation enhancer. |
| #8 | Xanthan Gum | Natural fermentation-derived polysaccharide stabilizer. |
| #9 | Glyceryl Polymethacrylate | Forms an invisible, breathable moisture net across the epidermis. |
| #10 | Ergothioneine | L-Ergothioneine (The Bodyguard). Mitochondrial-targeted antioxidant that quenches UV-induced ROS and inhibits MMP collagen breakdown. |
| #11 | Pyrroloquinoline Quinone Disodium Salt | PQQ Disodium Salt (The Generator). Stimulates mitochondrial biogenesis via CREB and PGC-1alpha and sustains up to 5,000x more redox cycles than Vitamin C. |
| #12 | Sodium Hyaluronate | Low-molecular-weight Hyaluronic Acid salt that binds up to 1,000x its weight in water. |
| #13 | Abronia Villosa Leaf Extract | Desert Sand Verbena. Extremophile desert plant extract that shields skin against heat and environmental stress. |
| #14 | Acetyl Hexapeptide-8 | Argireline. Neuro-modulating hexapeptide that softens dynamic expression and squint lines. |
| #15 | Acetyl Octapeptide-3 | SNAP-8. Advanced octapeptide partner to Argireline that targets deeper repetitive forehead and crow's feet creases. |
| #16 | Palmitoyl Tripeptide-1 | Matrixyl Signal Peptide. Fatty-acid-linked tripeptide that signals fibroblasts to support firmer collagen density. |
| #17 | Silk Amino Acids | Supplies bioavailable glycine, alanine, and serine to replenish Natural Moisturizing Factor (NMF). |
| #18 | Acrylates/C10-30 Alkyl Acrylate Crosspolymer | Ensures a silky, non-tacky glide across the skin. |
| #19 & #23 | 1,2-Hexanediol & 1,2-Pentanediol | Dual-carrier penetration solvents that enhance active absorption while conditioning the barrier. |
| #20 & #21 | Caprylhydroxamic Acid & Ethylhexylglycerin | Gentle, coconut-derived, 100% phenoxyethanol-free preservation and chelating system that works at neutral pH. |
| #22 | Parfum | Ultra-trace hypoallergenic aromatic note (<0.05% trace tier). |
| #24 | Portulaca Oleracea Extract | Purslane Extract. Longevity botanical rich in glutathione and omega-3s to soothe stressed, reactive skin. |
Unlike unstable L-Ascorbic Acid (Vitamin C) or Copper Peptides that conflict with other actives, PQQ and L-Ergothioneine are 100% pH-stable and layer effortlessly with your entire routine.
Start with clean, slightly damp skin after your morning rinse.
Press evenly over face, eye contour, neck, and chest. Because PQQ and L-Ergothioneine do not rely on acidic pH to penetrate, there is zero stinging or flushing.
Lock in with moisturiser and broad-spectrum sunscreen. While SPF blocks surface UV rays, Mito-Reset neutralizes the sub-surface mitochondrial ROS leak and relaxes daylight squint lines all day long.
AM · MITO-RESET: PQQ + L-Ergothioneine + 3 Peptides + Niacinamide. Sparks new mitochondrial biogenesis, clears daytime UV free radicals, and relaxes dynamic expression lines under SPF.
PM · MITO-MATRIX: Pure NAD+ + GHK-Cu Copper Peptide + Panthenol. Fuels overnight SIRT1/PARP-1 DNA repair and rebuilds deep dermal collagen while you sleep.
SHOP THE MITO-RESET + MITO-MATRIX DUOAureluxa. A New Era of Skincare. Cosmetic skincare, not medical advice. Our products are cosmetic formulations designed to support the visible appearance of firmer, brighter, smoother-looking skin and are not intended to diagnose, treat, cure, or prevent any disease. Scientific references to PQQ (Pyrroloquinoline Quinone Disodium Salt), L-Ergothioneine, and peptides cite third-party peer-reviewed biochemical literature on individual ingredients and do not represent clinical trials on the finished Mito-Reset formulation.
ROUTINE COMPARISON
| Consideration | Conventional Vitamin C serum | Retinoid-focused routine | Mito-Reset |
|---|---|---|---|
| Primary focus | Antioxidant support | Cell-turnover support | Mitochondrial biogenesis + defense |
| Signature ingredients | Vitamin C | Retinoid, formula dependent | PQQ Disodium Salt + L-Ergothioneine |
| Peptide system | Formula dependent | Formula dependent | Argireline + SNAP-8 + Palmitoyl Tripeptide-1 |
| Barrier support | Formula dependent | Formula dependent | Niacinamide #4 + Panthenol #5 |
| Routine position | Usually AM | Usually PM | AM under moisturiser + SPF 50+ |
L-ERGOTHIONEINE + PQQ · TRIPLE PEPTIDES · 30 ML
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